The impact of non‐motor symptoms on health‐related quality of life of patients with Parkinson's disease
Identifieur interne : 000126 ( Main/Exploration ); précédent : 000125; suivant : 000127The impact of non‐motor symptoms on health‐related quality of life of patients with Parkinson's disease
Auteurs : Pablo Martinez-Martin [Espagne] ; Carmen Rodriguez-Blazquez [Espagne] ; Monica M. Kurtis [Espagne] ; K. Ray Chaudhuri [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-02-15.
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Abstract
Background:: Non‐motor symptoms are detrimental to health‐related quality of life (HRQoL) of Parkinson's disease patients. In this study, the Non‐Motor Symptoms Scale (NMSS) was used to assess the impact of the non‐motor symptoms on HRQoL of Parkinson's disease patients. Methods:: In a multicenter, international, cross sectional study on 411 Parkinson's disease patients, the NMSS was applied along with clinical (Hoehn and Yahr staging and SCOPA‐Motor) and HRQoL measures (PDQ‐39, and EQ‐5D). Prevalence of non‐motor symptoms was determined also through the NMSS. The association of NMSS and SCOPA‐Motor with HRQoL measures and the differences in HRQoL scores between patients with and without non‐motor symptoms in each NMSS domain were estimated by non‐parametric statistics. Predictors of HRQoL were sought through multiple linear regression analyses. Results:: Nocturia (68.4% of the sample), fatigue (65.9%), and dribbling saliva (56.7%), were the most frequent complaints. Total NMSS score: (1) showed a higher correlation coefficient (rS = 0.70) with the PDQ‐39 Summary Index (SI) than SCOPA‐Motor (rS = 0.58); (2) showed high‐moderate correlation (rS = 0.60 − 0.38) with all PDQ‐39 domains; and (3) was the best predictor of HRQoL as measured by the PDQ‐39 SI. For each NMSS domain, patients with symptoms had significantly worse HRQoL scores than patients without symptoms. Discussion:: To our knowledge, this is the first study to determine in a holistic manner the impact of the non‐motor symptoms on HRQoL of Parkinson's disease patients. The results show that non‐motor symptoms have, as a whole, a greater impact on HRQoL than motor symptoms and non‐motor symptoms progression contributes importantly to HRQoL decline in patients with Parkinson's disease. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23462
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Ray Chaudhuri</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:1085E7D886BB491D7DE6A95F31C94E0635468F47</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/mds.23462</idno><idno type="url">https://api.istex.fr/document/1085E7D886BB491D7DE6A95F31C94E0635468F47/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000B51</idno><idno type="wicri:Area/Main/Curation">000A09</idno><idno type="wicri:Area/Main/Exploration">000126</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">The impact of non‐motor symptoms on health‐related quality of life of patients with Parkinson's disease</title><author><name sortKey="Martinez Artin, Pablo" sort="Martinez Artin, Pablo" uniqKey="Martinez Artin P" first="Pablo" last="Martinez-Martin">Pablo Martinez-Martin</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Area of Applied Epidemiology, National Centre of Epidemiology and CIBERNED, Carlos III Institute of Health, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Scientific Management, Alzheimer Disease Research Unit, CIEN Foundation, Carlos III Institute of Health, Alzheimer Center Reina Sofia Foundation, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Rodriguez Lazquez, Carmen" sort="Rodriguez Lazquez, Carmen" uniqKey="Rodriguez Lazquez C" first="Carmen" last="Rodriguez-Blazquez">Carmen Rodriguez-Blazquez</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Area of Applied Epidemiology, National Centre of Epidemiology and CIBERNED, Carlos III Institute of Health, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Kurtis, Monica M" sort="Kurtis, Monica M" uniqKey="Kurtis M" first="Monica M." last="Kurtis">Monica M. Kurtis</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Movement Disorders Unit, Department of Neurology, Ruber International Hospital, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Chaudhuri, K Ray" sort="Chaudhuri, K Ray" uniqKey="Chaudhuri K" first="K. Ray" last="Chaudhuri">K. Ray Chaudhuri</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Parkinson Foundation Centre of Excellence, Kings College Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurology, University Hospital Lewisham, Kings College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-02-15">2011-02-15</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="399">399</biblScope><biblScope unit="page" to="406">406</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">1085E7D886BB491D7DE6A95F31C94E0635468F47</idno><idno type="DOI">10.1002/mds.23462</idno><idno type="ArticleID">MDS23462</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>EQ‐5D</term><term>Parkinson's disease</term><term>Parkinson's disease questionnaire‐39 items</term><term>assessment</term><term>health‐related quality of life</term><term>non motor symptoms scale</term><term>non‐motor symptoms</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background:: Non‐motor symptoms are detrimental to health‐related quality of life (HRQoL) of Parkinson's disease patients. In this study, the Non‐Motor Symptoms Scale (NMSS) was used to assess the impact of the non‐motor symptoms on HRQoL of Parkinson's disease patients. Methods:: In a multicenter, international, cross sectional study on 411 Parkinson's disease patients, the NMSS was applied along with clinical (Hoehn and Yahr staging and SCOPA‐Motor) and HRQoL measures (PDQ‐39, and EQ‐5D). Prevalence of non‐motor symptoms was determined also through the NMSS. The association of NMSS and SCOPA‐Motor with HRQoL measures and the differences in HRQoL scores between patients with and without non‐motor symptoms in each NMSS domain were estimated by non‐parametric statistics. Predictors of HRQoL were sought through multiple linear regression analyses. Results:: Nocturia (68.4% of the sample), fatigue (65.9%), and dribbling saliva (56.7%), were the most frequent complaints. Total NMSS score: (1) showed a higher correlation coefficient (rS = 0.70) with the PDQ‐39 Summary Index (SI) than SCOPA‐Motor (rS = 0.58); (2) showed high‐moderate correlation (rS = 0.60 − 0.38) with all PDQ‐39 domains; and (3) was the best predictor of HRQoL as measured by the PDQ‐39 SI. For each NMSS domain, patients with symptoms had significantly worse HRQoL scores than patients without symptoms. Discussion:: To our knowledge, this is the first study to determine in a holistic manner the impact of the non‐motor symptoms on HRQoL of Parkinson's disease patients. The results show that non‐motor symptoms have, as a whole, a greater impact on HRQoL than motor symptoms and non‐motor symptoms progression contributes importantly to HRQoL decline in patients with Parkinson's disease. © 2011 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Espagne</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Communauté de Madrid</li><li>Grand Londres</li></region><settlement><li>Londres</li><li>Madrid</li></settlement></list><tree><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Martinez Artin, Pablo" sort="Martinez Artin, Pablo" uniqKey="Martinez Artin P" first="Pablo" last="Martinez-Martin">Pablo Martinez-Martin</name></region><name sortKey="Kurtis, Monica M" sort="Kurtis, Monica M" uniqKey="Kurtis M" first="Monica M." last="Kurtis">Monica M. Kurtis</name><name sortKey="Martinez Artin, Pablo" sort="Martinez Artin, Pablo" uniqKey="Martinez Artin P" first="Pablo" last="Martinez-Martin">Pablo Martinez-Martin</name><name sortKey="Rodriguez Lazquez, Carmen" sort="Rodriguez Lazquez, Carmen" uniqKey="Rodriguez Lazquez C" first="Carmen" last="Rodriguez-Blazquez">Carmen Rodriguez-Blazquez</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Chaudhuri, K Ray" sort="Chaudhuri, K Ray" uniqKey="Chaudhuri K" first="K. Ray" last="Chaudhuri">K. Ray Chaudhuri</name></region><name sortKey="Chaudhuri, K Ray" sort="Chaudhuri, K Ray" uniqKey="Chaudhuri K" first="K. Ray" last="Chaudhuri">K. Ray Chaudhuri</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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